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Metabolic profiling and toxicity of new psychoactive substances in a coastal wetland microcosms

AuthorsAndrés-Costa, María Jesús; Cotter, A.; Picó, Yolanda
Issue Date26-Jun-2018
Citation14th annual LC/MS/MS Workshop on Environmental Applications and Food Safety (2018)
AbstractNew psychoactive substances (NPS) include those that were not listed in the 1961 United Nations Single Convention on Narcotic Drugs or in the 1971, United Nations Convention on Psychotropic Substances and that are not controlled by legislation yet. The phenomenon of NPS is dynamic because the uncontrolled recreational drugs proliferating in number and variety. A total of 100 NPS were officially notified for the first time in the EU in 2015 through the EWS (Early Warning System), enlarging the total number of NPS monitored by EMCDDA to 560 – more than twice the number of drugs controlled under the international drug control conventions (EMCDDA, 2016). NPS are an unknown threat to the environmental since nothing is now about their (bio)degradation or the nature and hazard of these degradation products. This study was aimed at determining the potential for aerobic biodegradation as well as the main transformation products of bufotenine and 4-methoxyphencyclidine in a coastal wetland system. The specific objectives of this study were (i) to apply developed methodologies in water analysis (surface water), (ii) to estimate the bio- and photodegradation and transformation of the stereoisomers of selected NPS in surface water, and (iii) to evaluate the toxicity of these NPS at different trophic levels by in-silico and in-vivo studies. The two selected NPS were previously detected in Turia River basin (Andrés-Costa et al., 2017). The surface water sample was collected from l’Albufera Natural Park that is a coastal lagoon feed by this river. The applied analytical methodology was developed in previous studies (Andrés-Costa et al., 2017). L’Albufera water microcosm experiments were conducted in the light (L) and dark (D) conditions (to study photochemical processes) and biotic (B) or abiotic (A) conditions with or without sodium azide, respectively (as an inhibitor to microbiological processes). Light conditions were simulated with an Osram 400 W HQI BT daylight lamp during 8 h each day and dark conditions covering up the flask with foil completely. The experiment was carried out for 16 days and samples were taken daily. Toxicity tests were carried out in Daphnia magna (acute 48 h immobilization assay) following the standard operational procedure in accordance to the ISO standard 6341:2012 and the OECD 202 guideline. Lake simulating microcosms revealed that degradation of both NPS takes place via photochemical reactions (mostly hydroxylation). The toxicity tests show no short-term environmental risk might be expected at detected concentrations of NPS in environmental water samples. However, long-term effects have still to be assessed.
DescriptionTrabajo presentado en el 14th annual LC/MS/MS Workshop on Environmental Applications and Food Safety, celebrado en Barcelona (España) del 26 al 27 de junio de 2018
Appears in Collections:(CIDE) Comunicaciones congresos
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