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Título: | The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria |
Autor: | Muñoz-Espín, Daniel; Daniel, Richard; Kawai, Yoshikazu; Carballido-Lopez, Rut; Castilla-Llorente, Virginia; Errington, Jeff; Meijer, Wilhelmus J. J.; Salas, Margarita CSIC ORCID | Palabras clave: | Bacillus subtilis phage 29 |
Fecha de publicación: | 20-abr-2009 | Citación: | Proceedings of the National Academy of Sciences of the United States of America 106: 13347- 13352 (2009) | Resumen: | Little is known about the organization or proteins involved in membrane-associated replication of prokaryotic genomes. Here we show that the actin-like MreB cytoskeleton of the distantly related bacteria Escherichia coli and Bacillus subtilis is required for efficient viral DNA replication. Detailed analyses of B. subtilis phage φ29 showed that the MreB cytoskeleton plays a crucial role in organizing phage DNA replication at the membrane. Thus, phage double-stranded DNA and components of the φ29 replication machinery localize in peripheral helix-like structures in a cytoskeleton-dependent way. Importantly, we show that MreB interacts directly with the φ29 membrane-protein p16.7, responsible for attaching viral DNA at the cell membrane. Altogether, the results reveal another function for the MreB cytoskeleton and describe a mechanism by which viral DNA replication is organized at the bacterial membrane. | URI: | http://hdl.handle.net/10261/184128 | DOI: | 10.1073/pnas.0906465106 | Identificadores: | doi: 10.1073/pnas.0906465106 issn: 1091-6490 |
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