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Palladium (II) and platinum (II) complexes containing organometallic thiosemicarbazone ligands: Synthesis, characterization, X-ray structures and antitubercular evaluation

AuthorsArancibia, Rodrigo; Quintana, Cristobal; Biot, Christophe; Medina, Manuela E. CSIC; Carrère-Kremer, Séverine; Kremer, Laurent; Klahn, A. Hugo
KeywordsMycobacterium tuberculosis
Antitubercular activity
Organometallic thiosemicarbazone complexes
Issue DateMay-2015
CitationInorganic Chemistry Communication 55: 139-142 (2015)
AbstractA new series of palladium (II) and platinum (II) complexes containing ferrocenyl and cyrhetrenyl thiosemicarbazone ligands were synthesized and characterized. The two-step reaction of the organometallic thiosemicarbazones with i) K2MCl4 and ii) PPh3 and their subsequent recrystallization from CH2Cl2/hexane yielded the binuclear complexes [M {MLn(η5-C5H4)C(H)=NN=C(S)-NHR}-(Cl)(PPh3)] (M′=Pd, Pt; MLn=Re(CO)3, FeCp; R=H, CH3). The structures of the products were inferred from elemental analyses and IR, 1H and 31P NMR spectroscopies. The molecular structures of 2b and 3d were confirmed by single crystal X-ray analysis. All complexes were screened in vitro against Mycobacterium tuberculosis and exhibited only moderate activity in the low micromolar range.
Publisher version (URL)https://doi.org/10.1016/j.inoche.2015.03.036
Identifiersdoi: 10.1016/j.inoche.2015.03.036
issn: 1387-7003
Appears in Collections:(ICMM) Artículos
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