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dc.contributor.authorRoig-Roig, Ferranes_ES
dc.contributor.authorSoláns, Conxitaes_ES
dc.contributor.authorEsquena, Jordies_ES
dc.contributor.authorGarcía-Celma, María Josées_ES
dc.date.accessioned2019-06-05T10:58:09Z-
dc.date.available2019-06-05T10:58:09Z-
dc.date.issued2013-10-15-
dc.identifier.citationJournal of Applied Polymer Science 130 (2): 1377-1382 (2013)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/183396-
dc.description.abstractHyaluronic acid (HA) is a natural polysaccharide that is widely distributed in the human body. Its physicochemical properties and high biocompatibility make it a good candidate for biomedical and pharmaceutical uses. In the present work, we report HA-based hydrogels that could be applied as drug delivery systems or as implants for the treatment of joint diseases. We use butanediol diglycidyl ether as a chemical crosslinker to obtain HA hydrogels. Using a new dissolution tester and ketoprofen (KP) as a model drug, we study the release properties of the hydrogels. We obtain homogeneous and transparent hydrogels with high strength and elasticity. The swelling ratio (SR) depends on the crosslinker concentration and pH of the medium. We also reveal differences between the release profile of KP from swollen and unswollen hydrogels. The characteristics and differences in KP release profiles depending on the SR suggest the possibility of obtaining controlled release from HA-based hydrogels. © 2013 Wiley Periodicals, Inc.es_ES
dc.description.sponsorshipThe authors acknowledge financial support from the Spanish Ministerio de Economia y Competitividad (CTQ 2011‐29336‐C03/PPQ) and Generalitat de Catalunya (2009 SGR 961).es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectEmulsionses_ES
dc.subjectEmulsificationes_ES
dc.subjectBiomedical applicationses_ES
dc.subjectCrosslinkinges_ES
dc.titlePreparation, characterization, and release properties of hydrogels based on hyaluronan for pharmaceutical and biomedical usees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/app.39306-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/app.39306es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.contributor.orcidEsquena, Jordi [0000-0002-9188-5259]es_ES
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