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Title

A roadmap to the standardization of in vivo magnetic hyperthermia

AuthorsAsín, Laura; Beola, Lilianne; Grazú, Valeria; Gutiérrez, Lucía
Issue Date2018
Citation12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers (2018)
AbstractDespite the fact that magnetic hyperthermia seems to be a promising approach in cancer treatment, the lack of standardization in the treatment conditions and the difficulties measuring the biological effects make it difficult to compare results from different research groups. 33 publications on in vivo pre-clinical studies using magnetic hyperthermia have been compared to generate an overview of the current state of the art and trends in this topic. There seems to be an agreement in some of the parameters that affect the final efficacy of the hyperthermia treatment. For example, regarding the composition of the materials, iron oxides are the most popular ones being used in 68% of the studies. More variability has been detected regarding the field amplitude and frequency conditions (Fig. 1). This is a consequence of the heterogeneity of the instrumentation used for hyperthermia applications, as the vast majority of the research papers reported homemade equipment. This variability leads to a plethora of field amplitudes and frequencies resulting in a very broad range of conditions used for the in vivo experiments (Fig.1). Among other relevant parameters, high variability has also been observed regarding the length of the hyperthermia treatment, the number of repetitions of the alternating magnetic field exposure or the intervals between them (Fig. 2), It should also be noted that most of the manuscripts revised for this work did not provide a complete description of the materials and methodology used. This is a consequence of the multitude of parameters that are involved in such complex animal experiments. However, the limited access to these details makes even more complex the comparison between research works A bigger effort should be paid by our scientific community to standardize the different relevant parameters having such a complex influence on the final clinical performance of magnetic nanoparticles during in vivo hyperthermia treatments.
DescriptionResumen del trabajo presentado a la 12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, celebrada en Copenhague (Dinamarca) del 22 al 26 de mayo de 2018.
URIhttp://hdl.handle.net/10261/183366
Appears in Collections:(ICMA) Comunicaciones congresos
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