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Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches

AuthorsBecerril, Adriana; Álvarez, Susana; Braña, Alfredo F.; Rico, Sergio ; Díaz, Margarita ; Santamaría, Ramón I. ; Salas, Jose A; Méndez, Carmen
Issue Date24-May-2018
PublisherPublic Library of Science
CitationPLoS ONE 13(5): e0198145 (2018)
AbstractSequencing of Streptomyces genomes has revealed they harbor a high number of biosynthesis gene cluster (BGC), which uncovered their enormous potentiality to encode specialized metabolites. However, these metabolites are not usually produced under standard laboratory conditions. In this manuscript we report the activation of BGCs for antimycins, carotenoids, germicidins and desferrioxamine compounds in Streptomyces argillaceus, and the identification of the encoded compounds. This was achieved by following different strategies, including changing the growth conditions, heterologous expression of the cluster and inactivating the adpAa or overexpressing the abrC3 global regulatory genes. In addition, three new carotenoid compounds have been identified.
Publisher version (URL)https://doi.org/10.1371/journal.pone.0198145
Appears in Collections:(IBFG) Artículos
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