Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/183189
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Regulation of BDNF release by ARMS/Kidins220 through modulation of synaptotagmin-IV levels |
Autor: | López-Benito, Saray; Sánchez-Sánchez, Julia; Brito, Verónica; Calvo, Laura; Lisa, Silvia CSIC; Torres-Valle, María; Palko,Mary E.; Vicente García, Cristina; Fernandez-Fernandez, Seila CSIC; Bolaños, Juan P. CSIC ORCID; Ginés, Silvia; Tessarollo, Lino; Arévalo, Juan Carlos | Palabras clave: | ARMS/Kidins220 BDNF Huntington's disease Secretion Synaptotagmin IV |
Fecha de publicación: | 6-jun-2018 | Editor: | Society for Neuroscience | Citación: | Journal of Neuroscience 38(23): 5415-5428 (2018) | Resumen: | BDNF is a growth factor with important roles in the nervous system in both physiological and pathological conditions, but the mechanisms controlling its secretion are not completely understood. Here, we show that ARMS/Kidins220 negatively regulates BDNF secretion in neurons from the CNS and PNS. Downregulation of the ARMS/Kidins220 protein in the adult mouse brain increases regulated BDNF secretion, leading to its accumulation in the striatum. Interestingly, two mouse models of Huntington's disease (HD) showed increased levels of ARMS/Kidins220 in the hippocampus and regulated BDNF secretion deficits. Importantly, reduction of ARMS/Kidins220 in hippocampal slices from HD mice reversed the impaired regulated BDNF release. Moreover, there are increased levels of ARMS/Kidins220 in the hippocampus and PFC of patients with HD. ARMS/Kidins220 regulates Synaptotagmin-IV levels, which has been previously observed to modulate BDNF secretion. These data indicate that ARMS/Kidins220 controls the regulated secretion of BDNF and might play a crucial role in the pathogenesis of HD. | Versión del editor: | https://doi.org/10.1523/JNEUROSCI.1653-17.2018 | URI: | http://hdl.handle.net/10261/183189 | DOI: | 10.1523/JNEUROSCI.1653-17.2018 | E-ISSN: | 1529-2401 |
Aparece en las colecciones: | (IBFG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Regulation of BDNF_LopezBenito.pdf | 3,82 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 17-abr-2024
SCOPUSTM
Citations
21
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
18
checked on 27-feb-2024
Page view(s)
214
checked on 23-abr-2024
Download(s)
121
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.