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Title

Heat effect of nanoparticles for biotechnological applications

AuthorsFuente, Jesús M. de la
Issue Date2018
Citation8th Forum on New Materials - CIMTEC 2018
AbstractIn this talk we describe the synthesis and functionalization of magnetic and gold nanoparticles as therapeutic and diagnosis tools against cancer: -Gold nanoprisms (NPRs) have been functionalized with PEG, glucose, cell penetrating peptides, antibodies and/or fluorescent dyes, aiming to enhance NPRs stability, cellular uptake and imaging capabilities. Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination, these nanoprobes can cause apoptosis. The nanoparticles have also been used for optoacoustic imaging and tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support. -Magnetic nanoparticles functionalized with DNA molecules and further hybridizing with different length fluorophore-modified DNA have allowed the determination of temperature spatial mapping induced by the application of an alternating magnetic field. Due to the design of these DNAs, different denaturalization temperatures could be achieved. The quantification of the denaturalized DNA, and by interpolation onto a Boltzmann fitting model, it has been possible to calculate the local temperature increments at different distances.
DescriptionResumen del trabajo presentado al 8th Forum on New Materials - CIMTEC, celebrado en Perugia (Italia) del 10 al 14 de junio de 2018.
URIhttp://hdl.handle.net/10261/183046
Appears in Collections:(ICMA) Comunicaciones congresos
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