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Title

Efficacy of β-Lactam/β-Lactamase Inhibitor Combinations for the Treatment of Bloodstream Infection Due to Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in Hematological Patients with Neutropenia

AuthorsGudiol, Carlota; Royo-Cebrecos, Cristina; Abdala, Edson; Akova, Murat; Álvarez-Marín, Rocío; Maestro-de la Calle, Guillermo; Cano, Ángela; Cervera, Carlos; Clemente, Wanessa T.; Martín-Dávila, Pilar; Freifeld, Alison; Gómez, Lucía; Gottlieb, Thomas; Gurguí, Mercè; Herrera, Fabián; Manzur, Adriana; Maschmeyer, Georg; Meije, Yolanda; Montejo, Miguel; Peghin, Maddalena; Rodríguez-Baño, Jesús; Ruiz-Camps, Isabel; Sukiennik, Teresa C.; Tebé, Cristian; Carratalà, Jordi
KeywordsESBLs
Bloodstream infections
Neutropenia
Beta-lactam/beta-lactamase inhibitors
Mortality
Issue DateAug-2017
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 61(8): e00164-17 (2017)
Abstractβ-Lactam/β-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum-β-lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem-sparing alternatives for the treatment of BSI due to ESBLs in these patients.
Publisher version (URL)https://doi.org/10.1128/AAC.00164-17
URIhttp://hdl.handle.net/10261/182777
DOI10.1128/AAC.00164-17
ISSN0066-4804
E-ISSN1098-6596
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