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Title

Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa

AuthorsValencia, Estela-Ynes; Espósito, Fernanda; Spira, Beny; Blázquez Gómez, Jesús ; Galhardo, Rodrigo
KeywordsPseudomonas aeruginosa
SOS response
Ciprofloxacin
recA
Issue DateMar-2017
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 61(3): 02107-16 (2017)
AbstractResistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
Publisher version (URL)https://doi.org/10.1128/AAC.02107-16
URIhttp://hdl.handle.net/10261/182765
DOI10.1128/AAC.02107-16
ISSN0066-4804
E-ISSN1098-6596
Appears in Collections:(CNB) Artículos
(IBIS) Artículos
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