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http://hdl.handle.net/10261/182745
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Rosado-Sánchez, Isaac | es_ES |
dc.contributor.author | Herrero-Fernández, Inés | es_ES |
dc.contributor.author | Álvarez-Ríos, Ana Isabel | es_ES |
dc.contributor.author | Genebat, Miguel | es_ES |
dc.contributor.author | Abad Carrillo, M. A. | es_ES |
dc.contributor.author | Ruiz-Mateos, Ezequiel | es_ES |
dc.contributor.author | Pulido, Federico | es_ES |
dc.contributor.author | González-García, Juan | es_ES |
dc.contributor.author | Montero, M. | es_ES |
dc.contributor.author | Bernal-Morell, Enrique | es_ES |
dc.contributor.author | Vidal, Francesc | es_ES |
dc.contributor.author | Leal, Manuel | es_ES |
dc.contributor.author | Pacheco, Yolanda M. | es_ES |
dc.date.accessioned | 2019-05-29T09:49:51Z | - |
dc.date.available | 2019-05-29T09:49:51Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy 61(8): e00605-17 (2017) | es_ES |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | http://hdl.handle.net/10261/182745 | - |
dc.description.abstract | We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance. | es_ES |
dc.description.sponsorship | The HIV BioBank, integrated in the Spanish AIDS Research Network, is supported by Instituto de Salud Carlos III, Spanish Health Ministry (grants RD06/0006/0035 and RD12/0017/0037), as part of the Plan Nacional R + D + I and cofinanced by ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) and Fundación para la investigación y prevención del SIDA en España (FIPSE). The RIS Cohort (CoRIS) is funded by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en SIDA by the RD12/0017/0018 project, as part of the Plan Nacional R + D + I, and cofinanced by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). The project number is RIS_EPICLIN 20/2015. This work was supported by grants from the Fondo de Investigación Sanitaria, ISCIII (FIS; PI14/01693), and the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (Proyecto de Investigación de Excelencia; CTS2593), and cofunded by Fondos Europeos para el Desarrollo Regional (FEDER). I. Rosado-Sánchez was supported by the Spanish AIDS Research Network of Excellence (RIS; RD12/0017/0029). Y. M. Pacheco was supported by the Fondo de Investigación Sanitaria through the Miguel Servet program (CPII13/00037) and by the Servicio Andaluz de Salud through the Nicolás Monardes program (C-0010/13). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Microbiology | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | CD4/CD8 T-cell ratio | es_ES |
dc.subject | Delayed cART | es_ES |
dc.subject | Low CD4 recovery | es_ES |
dc.subject | T-cell turnover | es_ES |
dc.subject | Thymic function | es_ES |
dc.subject | CD4/CD8 ratio | es_ES |
dc.subject | Antiretroviral therapy | es_ES |
dc.subject | Human immunodeficiency virus | es_ES |
dc.subject | Immunodiscordant | es_ES |
dc.title | A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1128/AAC.00605-17 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1128/AAC.00605-17 | es_ES |
dc.identifier.e-issn | 1098-6596 | - |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Sanidad, Servicios Sociales e Igualdad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | es_ES |
dc.contributor.funder | Red Española de Investigación en SIDA | es_ES |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003751 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007671 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 28559274 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
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