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A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects

AuthorsRosado-Sánchez, Isaac; Herrero-Fernández, Inés; Álvarez-Ríos, A. I.; Genebat, Miguel; Abad Carrillo, M. A.; Ruiz-Mateos, Ezequiel; Pulido, Federico; González-García, Juan; Montero, M.; Bernal-Morell, Enrique; Vidal, Francesc; Leal, Manuel CSIC; Pacheco, Yolanda M. CSIC ORCID
KeywordsCD4/CD8 T-cell ratio
Delayed cART
Low CD4 recovery
T-cell turnover
Thymic function
CD4/CD8 ratio
Antiretroviral therapy
Human immunodeficiency virus
Issue DateAug-2017
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 61(8): e00605-17 (2017)
AbstractWe explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.
Publisher version (URL)https://doi.org/10.1128/AAC.00605-17
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