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Phostimulation of semiconducting nanoparticles to control physiological functions in vivo

AuthorsMoros, María; Antognazza, Maria Rosa; Bossio, C; Onorato, Giada; Bauduin, Antonella; Marchesano, V.; Zangoli, M.; Tino, Angela; Lanzani, G.; Tortiglione, Claudia
Issue Date2018
Citation8th Forum on New Materials - CIMTEC 2018
AbstractThe latest designs of optoelectronic devices powered research on fundamental properties of light and how it interacts with matter. In the context of a living cell, this interaction is hampered by the complexity of the living matter, making technological advancement key aspect of this research. Nanotechnologies may provide unique tools to finely tune biological functions, through development of biocompatible light nanotransducers. Here we show the possibility to modulate cell function by photostimulation of polymer nanoparticles based on poly(3-hexylthiophene) (NP-P3HT), a conjugated polymer widely used in photovoltaic application. By using a freshwater polyp as model organism, presenting photic behaviour despite the absence of proper eyes, we show that NP-P3HT internalized into animal tissue enhances animal photosensitivity. Moreover, the peculiar capabilities of the polyp to regenerate missing parts of amputated body allowed us to investigate the potential of P3HT-NP to enhance tissue regeneration. We observed in treated animals a boost in the regeneration efficiency under light illumination, uncovering a new function of these light nanotransducers in regenerative medicine and opening up new scenario on future therapeutic purposes.
DescriptionResumen del trabajo presentado al 8th Forum on New Materials - CIMTEC, celebrado en Perugia (Italia) del 4 al 14 de junio de 2018.
Appears in Collections:(ICMA) Comunicaciones congresos
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