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dc.contributor.authorSánchez-Gutiérrez, Danieles_ES
dc.contributor.authorSáez, Auroraes_ES
dc.contributor.authorGómez-Gálvez, Pedroes_ES
dc.contributor.authorParadas, Carmenes_ES
dc.contributor.authorEscudero, Luis M.es_ES
dc.date.accessioned2019-05-23T10:24:01Z-
dc.date.available2019-05-23T10:24:01Z-
dc.date.issued2017-01-10-
dc.identifier.citationScientific Reports 7: 40444 (2017)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/182153-
dc.description.abstractNatural packed tissues are assembled as tessellations of polygonal cells. These include skeletal muscles and epithelial sheets. Skeletal muscles appear as a mosaic composed of two different types of cells: the “slow” and “fast” fibres. Their relative distribution is important for the muscle function but little is known about how the fibre arrangement is established and maintained. In this work we capture the organizational pattern in two different healthy muscles: biceps brachii and quadriceps. Here we show that the biceps brachii muscle presents a particular arrangement, based on the different sizes of slow and fast fibres. By contrast, in the quadriceps muscle an unbiased distribution exists. Our results indicate that the relative size of each cellular type imposes an intrinsic organization into natural tessellations. These findings establish a new framework for the analysis of any packed tissue where two or more cell types exist.es_ES
dc.description.sponsorshipL.M.E., D.S.-G. and P.G.-G. are supported by the Ramón y Cajal program (PI13/01347); the Spanish government grant BFU2011-25734; and ISCIII and FEDER funds PI13/01347. A.S. and L.M.E. are supported by Fundación Pública Andaluza Progreso y Salud (Consejería de Salud), ref. PI-0033-2014.es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleRules of tissue packing involving different cell types: human muscle organizationes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/srep40444-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1038/srep40444es_ES
dc.identifier.e-issn2045-2322-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderFundación Progreso y Saludes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
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