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Biotransformation of magnetic nanoparticles as a function of the coating in a rat model

AuthorsRuiz, Amalia ; Gutiérrez, Lucía ; Cáceres, Paolín R.; Santos, Djalma; Chaves, Sacha B.; Fascineli, Maria Luisa; García, Mínica P.; Azevedo, Ricardo, B.; Morales, M. P.
Issue Date2014
Citation10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers (2014)
AbstractLong-term studies of in vivo in murine models have shown that DMSA-coated nanoparticles accumulate in spleen, liver and lungs tissues during extended periods of time (at least up to 3 months) without any significant signs of toxicity detected. During that time, nanoparticles undergo a process of biotransformation either reducing their size, particle aggregation or both. Using a rat model, we have evaluated the transformations of magnetic nanoparticles injected at lower doses. We have found that low doses of magnetic nanoparticles are quickly metabolized by the animals. In fact, using a nanoparticle dose 4 times lower than in previous experiments, particles were not observed 24 h after the administration of DMSA-coated magnetic nanoparticles either in the liver or the lungs. Interestingly, an increased amount of ferritin, the iron storage protein, was observed in liver tissues from rats that were treated with the low dose of DMSA-coated magnetic nanoparticles in comparison with the control ones, suggesting a rapid metabolization of the particles into ferritin iron. Two particle coatings, DMSA and PEG, have been administered to the animals, to evaluate the role of the coating in the degradation of the particles. We have found that, in comparison with the DMSA coated nanoparticles, PEG-coated magnetic nanoparticles are still detectable in several organs 24 h after their administration at low doses (see liver tissue samples in the figure).Knowledge on the biodistribution, circulation time and degradation processes is required to gain a better understanding on the safety evaluation of this kind of nanomaterials for biomedical applications.
DescriptionPoster presented at the 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers that took place in Dresden (Germany) during June 10-14th, 2014.
Appears in Collections:(ICMM) Comunicaciones congresos
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