English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/181952
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery

AuthorsRodríguez-Navarro, Susana ; Fischer, Tomás; Luo, Ming-Juan; Antúnez, Oreto; Brettschneider, Susanne; Perez-Ortin, Jose E.; Reed, Robin; Hurt, Ed; Lechner, Johannes
Issue Date9-Jan-2004
Cell Press
CitationCell 116(1):75-86 (2004)
AbstractGene expression is a coordinated multistep process that begins with transcription and RNA processing in the nucleus followed by mRNA export to the cytoplasm for translation. Here we report the identification of a protein, Sus1, which functions in both transcription and mRNA export. Sus1 is a nuclear protein with a concentration at the nuclear pores. Biochemical analyses show that Sus1 interacts with SAGA, a large intranuclear histone acetylase complex involved in transcription initiation, and with the Sac3-Thp1 complex, which functions in mRNA export with specific nuclear pore proteins at the nuclear basket. DNA macroarray analysis revealed that Sus1 is required for transcription regulation. Moreover, chromatin immunoprecipitation showed that Sus1 is associated with the promoter of a SAGA-dependent gene during transcription activation. Finally, mRNA export is impaired in sus1 mutants. These data provide an unexpected connection between the SAGA histone acetylase complex and the mRNA export machinery
Description12 páginas, 7 figuras, 1 tabla. Material suplementario en: https://doi.org/10.1016/S0092-8674(03)01025-0. The SUS1 sequences have been deposited in GenBank with the accession number AY278445.
Publisher version (URL)https://doi.org/10.1016/S0092-8674(03)01025-0
Appears in Collections:(IBV) Artículos
Files in This Item:
File Description SizeFormat 
2004 Cell 116-75 Vers autor.pdf1,36 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.