Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/181853
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gómez-Gálvez, Pedro | es_ES |
dc.contributor.author | Vicente-Munuera, Pablo | es_ES |
dc.contributor.author | Tagua, Antonio | es_ES |
dc.contributor.author | Forja, Cristina | es_ES |
dc.contributor.author | Castro Cañal, Ana María | es_ES |
dc.contributor.author | Letrán, Marta | es_ES |
dc.contributor.author | Valencia-Expósito, Andrea | es_ES |
dc.contributor.author | Grima, Clara | es_ES |
dc.contributor.author | Bermúdez-Gallardo, Marina | es_ES |
dc.contributor.author | Serrano-Pérez-Higueras, Óscar | es_ES |
dc.contributor.author | Cavodeassi, Florencia | es_ES |
dc.contributor.author | Sotillos, Sol | es_ES |
dc.contributor.author | Martín-Bermudo, María D. | es_ES |
dc.contributor.author | Márquez, Alberto | es_ES |
dc.contributor.author | Buceta, Javier | es_ES |
dc.contributor.author | Escudero, Luis M. | es_ES |
dc.date.accessioned | 2019-05-21T08:55:46Z | - |
dc.date.available | 2019-05-21T08:55:46Z | - |
dc.date.issued | 2018-07-27 | - |
dc.identifier | doi: 10.1038/s41467-018-05376-1 | - |
dc.identifier | issn: 2041-1723 | - |
dc.identifier.citation | Nature Communications 9: 2960 (2018) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/181853 | - |
dc.description.abstract | As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term ¿scutoid¿. The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs. | - |
dc.description.sponsorship | Ministerio Español de Ciencia y Tecnología (grants numbers BFU2013-48988-C2-1-P and BFU2016-80797 to M.D.M.-B.). A.V.-E. is supported by a FPI studentship (BES-2014-068850) from the Ministerio de Economía y Competitividad. S.S. is supported by grant of the MICINN/FEDER to J.C.-G. Hombría (BFU2016-76528-P). F.C. work is funded by Spanish Government Grant BFU2014-55918 and BBVA Foundation Personal Grant IN[16]_BBM_BAS_0078. J.B. acknowledges core funding by Lehigh University. L.M.E. and P.G.-G. are supported by the Ramón y Cajal program (PI13/01347); L.M.E., A.M., and C.G. work is funded by the Ministry of Economy, Industry, and Competitiveness grant BFU2016-74975-P co-funded by FEDER funds. P.V.-M. is supported by a contract co-funded by the Asociación Fundación Española contra el Cáncer and the Seville University. A.M.C. is supported by Fundación Pública Andaluza Progreso y Salud (Consejería de Salud), ref. PI-0033-2014. C.F. and A.T. is supported by a contract from Sistema Nacional de Garantía Juvenil and Programa Operativo de Empleo Juvenil 2014–2020 | - |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-80797 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-48988-C2-1-P | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-76528-P | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Scutoids are a geometrical solution to three-dimensional packing of epithelia | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/s41467-018-05376-1 | - |
dc.relation.publisherversion | http://doi.org/10.1038/s41467-018-05376-1 | - |
dc.date.updated | 2019-05-21T08:55:46Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Lehigh University | - |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | - |
dc.contributor.funder | Fundación BBVA | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Fundación Progreso y Salud | - |
dc.contributor.funder | Asociación Española Contra el Cáncer | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100006280 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100007406 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 30054479 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (CBM) Artículos (CABD) Artículos (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
726418.pdf | 5,05 MB | Unknown | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
30
checked on 21-abr-2024
SCOPUSTM
Citations
86
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
78
checked on 26-feb-2024
Page view(s)
228
checked on 20-abr-2024
Download(s)
131
checked on 20-abr-2024