English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/181696
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Reassessing the Role of Entamoeba gingivalis in Periodontitis

AuthorsBonner, Mark; Fresno, Manuel ; Gironès, Núria ; Guillén, Nancy; Santi-Rocca, Jullien
KeywordsPeriodontitis
Infectious disease
Parasitic infection
Inflammation
Entamoeba gingivalis
Gingivitis
Issue Date29-Oct-2018
CitationFrontiers in cellular and infection microbiology 8 (2018)
AbstractThe protozoan Entamoeba gingivalis resides in the oral cavity and is frequently observed in the periodontal pockets of humans and pets. This species of Entamoeba is closely related to the human pathogen Entamoeba histolytica, the agent of amoebiasis. Although E. gingivalis is highly enriched in people with periodontitis (a disease in which inflammation and bone loss correlate with changes in the microbial flora), the potential role of this protozoan in oral infectious diseases is not known. Periodontitis affects half the adult population in the world, eventually leads to edentulism, and has been linked to other pathologies, like diabetes and cardiovascular diseases. As aging is a risk factor for the disorder, it is considered an inevitable physiological process, even though it can be prevented and cured. However, the impact of periodontitis on the patient's health and quality of life, as well as its economic burden, are underestimated. Commonly accepted models explain the progression from health to gingivitis and then periodontitis by a gradual change in the identity and proportion of bacterial microorganisms in the gingival crevices. Though not pathognomonic, inflammation is always present in periodontitis. The recruitment of leukocytes to inflamed gums and their passage to the periodontal pocket lumen are speculated to fuel both tissue destruction and the development of the flora. The individual contribution to the disease of each bacterial species is difficult to establish and the eventual role of protozoa in the fate of this disease has been ignored. Following recent scientific findings, we discuss the relevance of these data and propose that the status of E. gingivalis be reconsidered as a potential pathogen contributing to periodontitis.
URIhttp://hdl.handle.net/10261/181696
Identifiersdoi: 10.3389/fcimb.2018.00379
issn: 2235-2988
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
GironésN_ReassessingTheRole.pdf739,57 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.