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Title

Preliminary results on the uptake and biochemical response to water-exposure of Tamiflu® (oseltamivir phosphate) in two marine bivalves

AuthorsDallarés, Sara; Montemurro, Nicola; Pérez, Sandra; Rodríguez Sánchez, Neus; Solé, Montserrat
KeywordsOxidative stress
Oseltamivir carboxylate
Carboxylesterases
Antiviral drug
Bivalves
Issue DateJan-2019
PublisherTaylor & Francis
CitationJournal of Toxicology and Environmental Health, Part A 82(2): 75-85 (2019)
AbstractTamiflu® (oseltamivir phosphate, OST) is an antiviral drug used for the pandemic treatment of avian influenza but few data are available regarding its toxicity. It should be noted that acute adverse responses are not likely to occur due to low environmental presence of this drug. Nonetheless, water concentration levels of this compound may reach the µg/L range under influenza episodes. Bivalves are reliable sentinels of chemical exposure due to their low metabolism; however, biotransformation of drugs does occur in these aquatic invertebrates. Two species of bivalves, namely mussels Mytilus galloprovincialis and clams Ruditapes philippinarum, were exposed for 48 h to 100 µg/L OST. Hemolymph from control and treated bivalves was withdrawn and the presence of OST and its metabolite oseltamivir carboxylate (OST-C) determined by LC-MS/MS. Gills and digestive gland were excised from control and exposed bivalves and carboxylesterase (CE) activities measured using different substrates. In addition, antioxidant defences and lipid peroxidation levels were determined. Higher metabolism of OST seemed to occur in mussels, since both OST and OST-C were found in hemolymph, whereas in clams only the parent compound was detected. In contrast, biomarker responses were more evident in exposed clams which indicate that this species may be considered as more sensitive to OST exposure. CE-related activities successfully reflected OST exposure, with substrates 1-naphthyl acetate (1NA) and 1-naphthyl butyrate (1NB) displaying the highest sensitivity in the two bivalve species. Data thus indicate the usefulness of CE-related activities as biomarkers for OST exposure in bivalves
Description11 pages, 1 figure, 2 tables, supplementary material https://doi.org/10.1080/15287394.2018.1562393
Publisher version (URL)https://doi.org/10.1080/15287394.2018.1562393
URIhttp://hdl.handle.net/10261/181695
Identifiersdoi: 10.1080/15287394.2018.1562393
issn: 1528-7394
e-issn: 1087-2620
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(ICM) Artículos
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