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Título: | Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts |
Autor: | Torralba, Daniel; Mittelbrunn, María CSIC ORCID CVN; Sánchez-Madrid, Francisco | Fecha de publicación: | 2018 | Editor: | Nature Publishing Group | Citación: | Nature Communications 9 (2018) | Resumen: | Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats. | URI: | http://hdl.handle.net/10261/181635 | DOI: | 10.1038/s41467-018-05077-9 | Identificadores: | doi: 10.1038/s41467-018-05077-9 issn: 2041-1723 |
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MittelbrunnM_PrimingOfDendritic.pdf | 4,2 MB | Adobe PDF | Visualizar/Abrir |
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