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C75 activates malonyl-CoA sensitive and insensitive components of the CPT system

AutorNicot, Carine; Napal, Laura; Relat, Joana; González, Silvia; Llebaria, Amadeu; Woldegiorgis, Gebre; Marrero, Pedro F.; Haro, Diego
Palabras claveC75
CPT system
Fatty acid oxidation
Fecha de publicación5-nov-2004
CitaciónBiochemical and Biophysical Research Communications 325(3): 660-664 (2004)
ResumenCarnitine palmitoyltransferase I (CPT-I) and II (CPT-II) enzymes are components of the carnitine palmitoyltransferase shuttle system which allows entry of long-chain fatty acids into the mitochondrial matrix for subsequent oxidation. This system is tightly regulated by malonyl-CoA levels since this metabolite is a strong reversible inhibitor of the CPT-I enzyme. There are two distinct CPT-I isotypes (CPT-Iα and CPT-Iβ), that exhibit different sensitivity to malonyl-CoA inhibition. Because of its ability to inhibit fatty acid synthase, C75 is able to increase malonyl-CoA intracellular levels. Paradoxically it also activates long-chain fatty acid oxidation. To identify the exact target of C75 within the CPT system, we expressed individually the different components of the system in the yeast Pichia pastoris. We show here that C75 acts on recombinant CPT-Iα, but also on the other CPT-I isotype (CPT-Iβ) and the malonyl-CoA insensitive component of the CPT system, CPT-II.
Descripción5 pages, 2 figures.-- PMID: 15541339 [PubMed].-- Printed version published Dec 17, 2004.
Versión del editorhttp://dx.doi.org/10.1016/j.bbrc.2004.10.085
ISSN0006-291X (Print)
1090-2104 (Online)
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