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dc.contributor.authorOrtiz de Solorzano, Isabeles_ES
dc.contributor.authorAlejo, Teresaes_ES
dc.contributor.authorAbad Andrés, Miriames_ES
dc.contributor.authorBueno-Alejo, Carloses_ES
dc.contributor.authorMendoza, Graciaes_ES
dc.contributor.authorAndreu, Vanesaes_ES
dc.contributor.authorIrusta, S.es_ES
dc.contributor.authorSebastian, Victores_ES
dc.contributor.authorArruebo, Manueles_ES
dc.date.accessioned2019-05-16T10:26:02Z-
dc.date.available2019-05-16T10:26:02Z-
dc.date.issued2019-
dc.identifier.citationJournal of Colloid and Interface Science 533: 171-181 (2019)es_ES
dc.identifier.issn0021-9797-
dc.identifier.urihttp://hdl.handle.net/10261/181507-
dc.description.abstractBy combining the photothermal ability of copper sulphide nanoparticles (NPs) upon excitation with Near Infrared (NIR) Light and the thermo-responsive properties of the homemade oligo (ethylene glycol) methyl ether methacrylate copolymer we have obtained fragmentable nanocomposites able to release a carried drug on-demand after NIR-light triggering. A complete physico-chemical characterization of the resulting nanoparticles has been carried out and their degradation assessed at different temperatures. Herein, we have also evaluated the drug loading capacity of those nanoparticles and the temperature dependence in their drug release kinetics using bupivacaine hydrochloride as a model drug. For those hybrid nanoparticles, subcytotoxic doses on four different cell lines and their potential interference in cell metabolism, induction of apoptosis, and cell cycle have been evaluated by Alamar Blue fluorometry and flow cytometry.es_ES
dc.description.sponsorshipThe financial support was provided by the ERC Consolidator Grant program (ERC-2013-CoG-614715, NANOHEDONISM), which is gratefully acknowledged. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011 financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development Fund.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/614715es_ES
dc.rightsclosedAccesses_ES
dc.subjectThermosensitive polymeres_ES
dc.subjectCleavable nanoparticleses_ES
dc.subjectBupivacainees_ES
dc.subjectDrug deliveryes_ES
dc.subjectPhotothermales_ES
dc.subjectNIRes_ES
dc.titleCleavable and thermo-responsive hybrid nanoparticles for on-demand drug deliveryes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.jcis.2018.08.069-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jcis.2018.08.069es_ES
dc.identifier.e-issn1095-7103-
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.pmid30153594-
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