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Título

Phenolic compounds from Brazilian propolis with pharmacological activities

AutorMarcucci, María Cristina; Ferreres, Federico ; García-Viguera, Cristina ; Bankoba, V. S.; Castro, de S. L; Dantas, A. P.; Valente, P. H. M.; Paulino, Niraldo
Palabras clavePropolis
Antibacterial activity
Antitrypanosomal activity
Phenolic compounds
Relaxant effect
Fecha de publicaciónfeb-2001
EditorElsevier
CitaciónJournal of Ethnopharmacology 74(2): 105-112 (2001)
ResumenFour compounds were isolated from Brazilian propolis. They are identified as: (1) 3-prenyl-4-hydroxycinnamic acid (PHCA), (2) 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyrane (DCBEN), (3) 3,5-diprenyl-4-hydroxycinnamic acid (DHCA), and (4) 2,2-dimethyl-6-carboxyethenyl-8-prenyl-2H-1-benzopyran (DPB). The structures of the compounds were determined by MS and NMR techniques. All compounds were assayed against Trypanosoma cruzi and the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis. Compounds (1) to (4) were active against T. cruzi. Except (1), all compounds presented activity against the bacteria tested. When compounds (1)–(3) were tested in the guinea pig isolated trachea, all induced a relaxant effect similar to propolis extract.
Descripción8 pages, 1 figure, 3 tables.
Versión del editorhttp://dx.doi.org/10.1016/S0378-8741(00)00326-3
URIhttp://hdl.handle.net/10261/18149
DOI10.1016/S0378-8741(00)00326-3
ISSN0378-8741
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