Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/181345
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Acquired protective immune response in a fish-myxozoan model encompasses specific antibodies and inflammation resolution |
Autor: | Picard-Sánchez, Amparo CSIC; Estensoro, Itziar CSIC ORCID; Pozo, R. del CSIC; Piazzon de Haro, María Carla CSIC ORCID ; Palenzuela, Oswaldo CSIC ORCID ; Sitjà-Bobadilla, Ariadna CSIC ORCID | Palabras clave: | Acquired immune response Fish IgM Sparus aurata Enteromyxum leei Parasite resistance Gene expression |
Fecha de publicación: | jul-2019 | Editor: | Elsevier | Citación: | Fish & Shellfish Immunology 90: 349-362 (2019) | Resumen: | The myxozoan parasite Enteromyxum leei causes chronic enteritis in gilthead sea bream (GSB, Sparus aurata) leading to intestinal dysfunction. Two trials were performed in which GSB that had survived a previous infection with E. leei (SUR), and naïve GSB (NAI), were exposed to water effluent containing parasite stages. Humoral factors (total IgM and IgT, specific anti-E. leei IgM, total serum peroxidases), histopathology and gene expression were analysed. Results showed that SUR maintained high levels of specific anti-E. leei IgM (up to 16 months), expressed high levels of immunoglobulins at the intestinal mucosa, particularly the soluble forms, and were resistant to re-infection. Their acquired-type response was complemented by other immune effectors locally and systemically, like cell cytotoxicity (high granzyme A expression), complement activity (high c3 and fucolectin expression), and serum peroxidases. In contrast to NAI, SUR displayed a post-inflammatory phenotype in the intestine and head kidney, characteristic of inflammation resolution (low il1β, high il10 and low hsp90α expression). | Versión del editor: | https://doi.org/10.1016/j.fsi.2019.04.300 | URI: | http://hdl.handle.net/10261/181345 | DOI: | 10.1016/j.fsi.2019.04.300 | ISSN: | 1050-4648 | E-ISSN: | 1095-9947 |
Aparece en las colecciones: | (IATS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
REPOSITORIO FSI_2019_Accepted_manuscript.pdf | 14,17 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
23
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
17
checked on 26-feb-2024
Page view(s)
334
checked on 23-abr-2024
Download(s)
275
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.