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Title

RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

AuthorsArriortua, Oihane K.; Insausti, Maite; Lezama, Luis; Gil de Muro, Izaskun; Garaio, Eneko; Fuente, Jesús M. de la; Fratila, Raluca M.; Morales, M. P. ; Costa, Rocío; Eceiza, Maite; Sagartzazu-Aizpurua, Maialen; Aizpurua, Jesus M.
KeywordsCitotoxicity
EMR
Hyperthermia
RGD
Magnetite
Issue Date2018
PublisherElsevier
CitationColloids and Surfaces B: Biointerfaces 165: 315-324 (2018)
AbstractTo improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target αvβ3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles.
Publisher version (URL)https://doi.org/10.1016/j.colsurfb.2018.02.031
URIhttp://hdl.handle.net/10261/181288
DOI10.1016/j.colsurfb.2018.02.031
ISSN0927-7765
E-ISSN1873-4367
Appears in Collections:(ICMM) Artículos
(ICMA) Artículos
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