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Polymer-coated superparamagnetic iron oxide nanoparticles as T2 contrast agent for MRI and their uptake in liver

AuthorsAli, L. M. A.; Marzola, Pasquina; Nicolato, Elena; Fiorini, S.; Heras, Marcelo de las; Piñol, Rafael; Gabilondo, Lierni; Millán, Ángel; Palacio, Fernando
KeywordsContrast agent
Magnetic resonance imaging
Superparamagnetic iron oxide nanoparticles
Issue Date2018
PublisherFuture Science
CitationFuture Science OA 5(1): FSO235 (2018)
Abstract[Aim]: To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T2 magnetic resonance contrast agent and their uptake and toxicity in liver. [Materials & methods]: Mice were intravenously injected with bioferrofluids and Endorem®. The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. [Results]: Bioferrofluids are a good T2 contrast agent with a higher r2/r1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. [Conclusion]: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.
Publisher version (URL)https://doi.org/10.4155/fsoa-2017-0054
Appears in Collections:(ICMA) Artículos
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