Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/181204
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

New active formulations against M. tuberculosis: Bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules

AuthorsMatteis, Laura de; Jary, Dorothée; Lucía, Ainhoa; García-Embid, Sonia; Serrano-Sevilla, Inés; Pérez, Daniel; Aínsa, José A.; Navarro, Fabrice; Fuente, Jesús M. de la
KeywordsNanocarriers
Bedaquiline
Mycobacterium tuberculosis
Electron microscopy
Cytotoxicity
Issue Date2018
PublisherElsevier
CitationChemical Engineering Journal 340: 181-191 (2018)
AbstractIn the last years, the increase in antimicrobial resistance, together with a lack of new drugs for the treatment of bacterial infections resistant to classical antibiotics are of growing concern. Moreover, some of current therapies induce severe side effects and are often difficult to administer. In 2012 the FDA approved the use of bedaquiline, as the first new very effective drug against TB in the last 40 years. Despite its effectiveness, unfortunately bedaquiline side effects can be so dangerous that at present it is to be prescribed only when no other treatment options are available. The development of effective and safe nanotechnology-based methods can be particularly relevant to increase antimicrobial concentration at the site of infection, to reduce doses in the general circulation, which in turn reduces adverse effects. In this work bedaquiline was encapsulated in two types of nanocarriers, lipid nanoparticles and chitosan-based nanocapsules with high encapsulation efficiency and drug loading values. The efficacy of the drug-encapsulating nanocarriers has been demonstrated in vitro against Mycobacterium tuberculosis, together with the excellent compatibility of both carriers with animal cells. The obtained results open the way for further studies on multi-drug resistant strains of M. tuberculosis and for in vivo studies of the optimized nanocarriers. The promising behaviour of drug-loaded nanocarriers will hopefully lead to a reduction of the administered doses of a quite dangerous drug as bedaquiline, tuning its biodistribution and so decreasing its adverse effects, finally allowing its use in a higher number of patients.
Publisher version (URL)https://doi.org/10.1016/j.cej.2017.12.110
URIhttp://hdl.handle.net/10261/181204
DOI10.1016/j.cej.2017.12.110
ISSN1385-8947
Appears in Collections:(ICMA) Artículos

Files in This Item:
File Description SizeFormat
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

SCOPUSTM   
Citations

22
checked on Jan 15, 2022

WEB OF SCIENCETM
Citations

19
checked on Jan 15, 2022

Page view(s)

198
checked on Jan 19, 2022

Download(s)

25
checked on Jan 19, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.