English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/18109
Título

Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine

AutorGalindo, Ruth C. ; Muñoz, Pilar M. ; Miguel, María Jesús de; Marín, Clara M.; Blasco, José M.; Gortázar, Christian ; Kocan, Katherine M.; Fuente, José de la
Palabras claveBrucella
Vaccine
Sheep
Microarray
Genomics
Fecha de publicación7-abr-2009
EditorElsevier
CitaciónVaccine 27(23): 3039-3044 (2009)
ResumenVaccination with the live attenuated Brucella melitensis Rev 1 vaccine is used to control ovine brucellosis caused by Brucella ovis in sheep. The objective of this study was to identify possible correlates of protective response to B. ovis infection through the characterization by microarray hybridization and real-time RT-PCR of inflammatory and immune response genes differentially expressed in rams previously immunized with B. melitensis Rev 1 and experimentally challenged with B. ovis. Gene expression profiles were compared before and after challenge with B. ovis between rams protected and those vaccinated but found infected after challenge. The TLR10, Bak and ANXI genes were expressed at higher levels in vaccinated and protected rams. These genes provide possible correlates of protective response to B. ovis infection in rams immunized with the B. melitensis Rev 1 vaccine.
Descripción6 pages, 2 figures, 2 tables.-- PMID: 19428917 [PubMed].-- Printed version published May 18, 2009.
Versión del editorhttp://dx.doi.org/10.1016/j.vaccine.2009.03.046
URIhttp://hdl.handle.net/10261/18109
DOI10.1016/j.vaccine.2009.03.046
ISSN0264-410X
Aparece en las colecciones: (IREC) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.