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dc.contributor.authorRibeiro, Lígia .N. M.-
dc.contributor.authorAlcântara, Ana C. S.-
dc.contributor.authorDarder, Margarita-
dc.contributor.authorAranda, Pilar-
dc.contributor.authorHerrmann, Paulo .S. P. Jr.-
dc.contributor.authorAraújo-Moreira, Fernando M.-
dc.contributor.authorGarcía-Hernández, M.-
dc.contributor.authorRuiz-Hitzky, Eduardo-
dc.date.accessioned2019-05-07T10:44:14Z-
dc.date.available2019-05-07T10:44:14Z-
dc.date.issued2014-12-30-
dc.identifier.citationInternational journal of pharmaceutics 477(1-2): 553-563 (2014)-
dc.identifier.issn0378-5173-
dc.identifier.urihttp://hdl.handle.net/10261/181012-
dc.description.abstractNew magnetic bio-hybrid matrices for potential application in drug delivery are developed from the assembly of the biopolymer alginate and magnetic graphite nanoparticles. Ibuprofen (IBU) intercalated in a Mg-Al layered double hydroxide (LDH) was chosen as a model drug delivery system (DDS) to be incorporated as third component of the magnetic bionanocomposite DDS. For comparative purposes DDS based on the incorporation of pure IBU in the magnetic bio-hybrid matrices were also studied. All the resulting magnetic bionanocomposites were processed as beads and films and characterized by different techniques with the aim to elucidate the role of the magnetic graphite on the systems, as well as that of the inorganic brucite-like layers in the drug-loaded LDH. In this way, the influence of both inorganic components on the mechanical properties, the water uptake ability, and the kinetics of the drug release from these magnetic systems were determined. In addition, the possibility of modulating the levels of IBU release by stimulating the bionanocomposites with an external magnetic field was also evaluated in in vitro assays.-
dc.description.sponsorshipThis work was supported by the CICYT, Spain (project MAT2012-31759) and the EU COST Action MP1202. L.N.M.R. acknowledges the CAPES (Brazil) for her fellowship. FMAM acknowledges Brazilian agencies FAPESP, CAPES and CNPq for financial support.-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.subjectIbuprofen-
dc.subjectControlled release-
dc.subjectAlginate-
dc.subjectDrug delivery-
dc.subjectLayered double hydroxides-
dc.subjectBionanocomposites-
dc.subjectMagnetic graphite-
dc.titleBionanocomposites containing magnetic graphite as potential systems for drug delivery-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijpharm.2014.10.033-
dc.relation.publisherversionhttps://doi.org/10.1016/j.ijpharm.2014.10.033-
dc.date.updated2019-05-07T10:44:14Z-
dc.contributor.funderFundação de Amparo à Pesquisa do Estado de São Paulo-
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001807es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003593es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002322es_ES
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