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dc.contributor.authorEcheverría, Coro-
dc.contributor.authorAragón-Gutiérrez, Alejandro-
dc.contributor.authorFernández-García, Marta-
dc.contributor.authorMuñoz-Bonilla, Alexandra-
dc.contributor.authorLópez, Daniel-
dc.date.accessioned2019-04-29T10:49:59Z-
dc.date.available2019-04-29T10:49:59Z-
dc.date.issued2019-04-02-
dc.identifier.citationPolymers 11(4): 606 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/180716-
dc.description.abstractThe work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrobial peptides). The originality of this work lies in the possibility of developing intrinsic antimicrobial microgels by copolymerization of the well-known thermoresponsive monomer, <i>N</i>-isopropylacrylamide (NIPAM) with dimethylaminoethyl methacrylate (DMAEMA), a water-soluble monomer, to form microgels via precipitation polymerization (radical polymerization). Due to the presence of a tertiary amine in the DMAEMA comonomer, microgels can be modified by <i>N</i>-alkylation reaction with methyl and butyl iodide. This quaternization confers positive charges to the microgel surfaces and thus the potential antimicrobial activity. The effect of DMAEMA content and its quaternization with both, methyl and butyl iodide is evaluated in terms of thermal and surface charge properties, as well as in the microgel size and viscoelastic behavior. Finally, a preliminary study of the antimicrobial activity against different microorganisms is also performed in terms of minimum inhibitory concentration (MIC). From this study we determined that in contrast with butylated microgels, methylated ones show potential antimicrobial activity and good physical properties besides of maintaining microgel thermo-responsiveness.-
dc.description.sponsorshipThis work was funded by MAT2017-88123-P and MAT2016-78437-R (FEDER–EU). CE also acknowledges IJCI-2015-26432 contract from MINEICO.-
dc.description.sponsorshipWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationMINECO/ICTI2013-2016/MAT2017-88123-P-
dc.relationMINECO/ICTI2013-2016/MAT2016-78437-R-
dc.relationMINECO/ICTI2013-2016/IJCI-2015-26432-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectPolycationic microgels-
dc.subjectQuaternization-
dc.subjectAntimicrobial activity-
dc.subjectTemperature-responsive-
dc.titleThermoresponsive Poly(N-Isopropylacrylamide-co-Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/polym11040606-
dc.relation.publisherversionhttp://dx.doi.org/10.3390/polym11040606-
dc.identifier.e-issn2073-4360-
dc.date.updated2019-04-29T10:49:59Z-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-sa/4.0/-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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