English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/180593
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Evaluation of the health risks related to the presence of cyanogenic glycosides in foods other than raw apricot kernels

AuthorsSchrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Del Mazo, Jesús ; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius (Ron); Leblanc, Jean-Charles; Nebbia, Carlo Stefano; Nielsen, Elsa; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Vleminckx, Christiane; Wallace, Heather; Benford, Diane; Brimer, Leon; Mancini, Francesca Romana; Metzler, Manfred; Viviani, Bárbara
Cyanogenic glycosides
Health-based guidance values
Risk assessment
Issue DateApr-2019
PublisherJohn Wiley & Sons
CitationEFSA Journal 17(4) 5652 (2019)
AbstractIn 2016, the EFSA Panel on Contaminants in the Food Chain (CONTAM) published a scientific opinion on the acute health risks related to the presence of cyanogenic glycosides (CNGs) in raw apricot kernels in which an acute reference dose (ARfD) of 20 lg/kg body weight (bw) was established for cyanide (CN). In the present opinion, the CONTAM Panel concluded that this ARfD is applicable for acute effects of CN regardless the dietary source. To account for differences in cyanide bioavailability after ingestion of certain food items, specific factors were used. Estimated mean acute dietary exposures to cyanide from foods containing CNGs did not exceed the ARfD in any age group. At the 95th percentile, the ARfD was exceeded up to about 2.5-fold in some surveys for children and adolescent age groups. The main contributors to exposures were biscuits, juice or nectar and pastries and cakes that could potentially contain CNGs. Taking into account the conservatism in the exposure assessment and in derivation of the ARfD, it is unlikely that this estimated exceedance would result in adverse effects. The limited data from animal and human studies do not allow the derivation of a chronic health-based guidance value (HBGV) for cyanide, and thus, chronic risks could not be assessed.
Description78 p.-6 fig.-26 tab.-3 appendix
Publisher version (URL)https:// 10.2903/j.efsa.2019.5662
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
j.efsa_Del Mazo_2019.pdf8,2 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.