English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/180558
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Generation of a human iPS cell line from a patient with retinitis pigmentosa due to EYS mutation

AuthorsCalado, Sofia M.; García-Delgado, Ana B.; Cerda, Berta de la ; Ponte-Zuñiga, Beatriz; Bhattacharya, Shom Shanker ; Díaz-Corrales, Francisco J.
Issue DateDec-2018
PublisherElsevier
CitationStem Cell Research 33: 251-254 (2018)
AbstractRetinitis pigmentosa (RP) is an inherited retinal degenerative disease. Mutations in EYS have been associated with autosomal recessive RP. The human iPS cell line, CABi002-A, derived from peripheral blood mononuclear cells from a patient carrying a heterozygous double mutation in EYS gene was generated by non-integrative reprogramming technology, using hOCT3/4, hSOX2, hc-MYC and hKLF4 reprogramming factors. Pluripotency and differentiation capacity were assessed by immunocytochemistry and RT-PCR. This iPSC line can be further differentiated towards the affected cells to understand the pathophysiology of the disease and test new therapeutic strategies.
Publisher version (URL)https://doi.org/10.1016/j.scr.2018.11.002
URIhttp://hdl.handle.net/10261/180558
DOI10.1016/j.scr.2018.11.002
ISSN1873-5061
E-ISSN1876-7753
Appears in Collections:(CABIMER) Artículos
Files in This Item:
File Description SizeFormat 
Generation of a human iPS_Calado.pdf838,41 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.