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Pharmaceutically active protein crystals grown in-situ within a hydrogel

AuthorsCienfuegos Rodríguez, Luis Álvarez de; Gavira Gallardo, J. A. ; Díaz Mochón, Juan José; Conejero-Muriel, María Teresa; Contreras Montoya, Rafael
Issue Date9-Nov-2017
CitationWO2017191323 A1
AbstractThe present invention providesa process to manufacture a composition comprising a hydrogel comprising pharmaceutically active protein crystals grown in-situwithin the hydrogel, wherein the pharmaceutically active protein crystals grown in-situhave an average size ofless than 20 microns, which comprises: a. Sequentially blending a pharmaceutically active protein solution in their appropriate buffer composition by using a value of supersaturation in the metastable zone width (MSZW) or nearby the supersolubility curve, with a precipitant solution, wherein acetone is absent, and a gelator solution, b. Inducing the nucleation by lowering the temperature, and c. Storing the resulting mixtureat a constant temperature, preferably at room temperatureat 1 atm.
Appears in Collections:(IACT) Patentes
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