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http://hdl.handle.net/10261/180538
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Valero, Clara | es_ES |
dc.contributor.author | Amaveda, H. | es_ES |
dc.contributor.author | Mora Alfonso, Mario | es_ES |
dc.contributor.author | García-Aznar, Jose Manuel | es_ES |
dc.date.accessioned | 2019-04-25T09:58:04Z | - |
dc.date.available | 2019-04-25T09:58:04Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | PLoS ONE 13(4): e0195820 (2018) | es_ES |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10261/180538 | - |
dc.description.abstract | Collagen hydrogels are widely used for in-vitro experiments and tissue engineering applications. Their use has been extended due to their biocompatibility with cells and their capacity to mimic biological tissues; nevertheless their mechanical properties are not always optimal for these purposes. Hydrogels are formed by a network of polymer filaments embedded on an aqueous substrate and their mechanical properties are mainly defined by the filament network architecture and the individual filament properties. To increase properties of native collagen, such as stiffness or strain-stiffening, these networks can be modified by adding crosslinking agents that alter the network architecture, increasing the unions between filaments. In this work, we have investigated the effect of one crosslinking agent, transglutaminase, in collagen hydrogels with varying collagen concentration. We have observed a linear dependency of the gel rigidity on the collagen concentration. Moreover, the addition of transglutaminase has induced an earlier strain-stiffening of the collagen gels. In addition, to better understand the mechanical implications of collagen concentration and crosslinkers inclusion, we have adapted an existing computational model, based on the worm-like chain model (WLC), to reproduce the mechanical behavior of the collagen gels. With this model we can estimate the parameters of the biopolymer networks without more sophisticated techniques, such as image processing or network reconstruction, or, inversely, predict the mechanical properties of a defined collagen network. | es_ES |
dc.description.sponsorship | The work corresponding to C. Valero and J.M. García-Aznar was supported by the European Research Council (ERC) through project ERC-2012-StG 306571 and the Spanish Ministry of Economy and Competitiveness through the project DPI2015-64221-C2-1-R and by the Gobierno de Aragon (research group T86). The work corresponding to H. Amaveda and M.Mora was supported by the Spanish Ministry of Economy and Competitiveness and the European FEDER Program (project ENE1014-52105-R) and by the Gobierno de Aragón (research group T12). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/306571 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2015-64221-C2-1-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/ENE2014-52105-R | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Combined experimental and computational characterization of crosslinked collagenbased hydrogels | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0195820 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0195820 | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | European Research Council | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Gobierno de Aragón | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010067 | es_ES |
dc.identifier.pmid | 29664953 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (ICMA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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combihydrogel.pdf | 4,85 MB | Adobe PDF | Visualizar/Abrir |
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