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A facile method for the controlled polymerization of biocompatible and thermoresponsive oligo(ethylene glycol) methyl ether methacrylate copolymers

AuthorsAlejo, Teresa; Prieto, Martin; García-Juan, Hugo; Andreu, Vanesa; Mendoza, Gracia; Sebastian, Victor; Arruebo, Manuel
Issue Date2018
PublisherSpringer Nature
CitationPolymer Journal 50: 203-211 (2018)
AbstractPhotochemically controlled ATRP-like polymerization is successfully used to prepare a thermoresponsive copolymer of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and di(ethylene glycol) methyl ether methacrylate (MEO2MA). The photochemically controlled method described here provides good control over the polymer structure, architecture, and properties. This photopolymerization renders polymers with narrow molecular weight distributions (Mw/Mn = 1.3) and high monomer conversions (>90%) while using a very low iridium-based catalyst concentration (25 ppm). In addition, the reaction rate of this polymerization is fast, reaching 50% monomer conversion in less than 1 h of reaction. The lower critical solution temperature (LCST) of the prepared polymer was also adjusted to be in the range of physiological temperatures, undergoing a coil-to-globule transition at 43 °C. In addition, the resulting polymer showed no cytotoxicity on four mammalian cell lines at the highest concentration tested (0.4 mg/ml), which highlights its potential use in different biomedical applications.
Publisher version (URL)http://dx.doi.org/10.1038/s41428-017-0004-8
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