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Gene gating at nuclear pores prevents the formation of R loops

AuthorsGaillard, Hélène ; García-Benítez, Francisco
KeywordsGenome instability
Genome organization
Nuclear pores
R loop
Issue Date2018
PublisherTaylor & Francis
CitationMolecular and Cellular Oncology 5(1): e1405140 (2018)
AbstractTranscription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of chromatin to nuclear pores prevents the formation of pathological R loops during transcription. Our study opens new perspectives to understand genome stability as a function of nuclear location.
Publisher version (URL)https://doi.org/10.1080/23723556.2017.1405140
Appears in Collections:(CABIMER) Artículos
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