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Título: | Gene gating at nuclear pores prevents the formation of R loops |
Autor: | Gaillard, Hélène CSIC ORCID; García-Benítez, Francisco CSIC | Palabras clave: | Genome instability Genome organization Nuclear pores R loop Transcription |
Fecha de publicación: | 2018 | Editor: | Taylor & Francis | Citación: | Molecular and Cellular Oncology 5(1): e1405140 (2018) | Resumen: | Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of chromatin to nuclear pores prevents the formation of pathological R loops during transcription. Our study opens new perspectives to understand genome stability as a function of nuclear location. | Versión del editor: | https://doi.org/10.1080/23723556.2017.1405140 | URI: | http://hdl.handle.net/10261/180413 | DOI: | 10.1080/23723556.2017.1405140 | ISSN: | 2372-3556 |
Aparece en las colecciones: | (CABIMER) Artículos |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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