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Title

Oxazole/Thiazole and Triazole Hybrids Based on ¿-Amino Acids

AuthorsValdomir, Guillermo; Padrón, Juan I. ; Padrón, José M.; Martín, Víctor S.; Davyt, Danilo
KeywordsPeptides
Ring closure
Alkynes
Azides
Heterocycles
Issue Date2014
PublisherThieme
CitationSynthesis 46(18): 2451-2462 (2014)
AbstractThe Cu(I)-catalyzed Huisgen [3+2] cycloaddition is the basis of click chemistry to synthesize triazole derivatives by coupling azides with ethynyl blocks. In the development of new compounds inspired by bioactive natural products, the synthesis of new oxazole building blocks containing azide moiety and coupling them with aromatic alkynes via triazole linker is described. These oxazole building blocks are synthesized using amino acids as chiral and inexpensive starting materials. Using this approach, 16 new triazole-oxazole hybrids were synthesized.
Publisher version (URL)https://doi.org/10.1055/s-0033-1339139
URIhttp://hdl.handle.net/10261/180411
DOI10.1055/s-0033-1339139
Identifiersdoi: 10.1055/s-0033-1339139
issn: 0039-7881
e-issn: 1437-210X
Appears in Collections:(IPNA) Artículos
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