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Title

Bioactive compounds from transformed root cultures and aerial parts of Bethencourtia hermosae

AuthorsFraga, Braulio M. ; Díaz, Carmen E. ; Amador, Leonardo J.; Reina, Matías ; Santana, Omar; González-Coloma, Azucena
KeywordsCytotoxic Effects
Alkaloids
Transformed Roots
Insect Antifeedants
Bethencourtia Hermosae
Senecrassane
Ceratopicane
Africanane
Sesquiterpenes
Issue DateDec-2014
PublisherElsevier
CitationPhytochemistry 108: 220-228 (2014)
AbstractA chemical study of Bethencourtia hermosae, aerial parts and in vitro root cultures, transformed by Agrobacterium rhizogenes, afforded the hitherto unreported sesquiterpenes ceratopicanol angelate (1), 8β-hydroxy-african-4(5)-en-3-one tiglate (4), 8β-hydroxy-african-4(5)-en-3-one 3′-angeloxy-2′-methylbutanoate (5), 1α,8β-dihydroxy-african-4(5)-en-3-one 8β-angelate (7) and 6α,8β-dihydroxy-african-4(5)-en-3-one 8β-angelate (8). In addition, 8β-hydroxy-african-4(5)-en-3-one (6) was isolated for the first time from a natural source, along with the rare sesquiterpenoid senecrassidiol (10) and two jacaranone derivatives 14 and 16. Known pyrrolizidine alkaloids, together with previously unreported hermosine (23), have also been isolated from this plant. The insect antifeedant activities of the extracts and compounds were studied together with their cytotoxic effects against insect (Sf9) and mammalian (CHO) cell lines.
Publisher version (URL)https://doi.org/10.1016/j.phytochem.2014.09.010
URIhttp://hdl.handle.net/10261/180390
Identifiersdoi: 10.1016/j.phytochem.2014.09.010
issn: 0031-9422
e-issn: 1873-3700
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