English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/180374
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Metal-free, one-pot conversion of proline derivatives into 2-aryl-3-iodo pyrrolidines by a sequential scission-iodination-arylation process

AuthorsBatchu, Venkateswara Rao ; Romero Estudillo, Iván Omar; Boto, Alicia ; Miguélez, Javier
Issue Date2014
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 12(47): 9547-9556 (2014)
AbstractThe metal-free, direct conversion of readily available proline derivatives into 2-aryl-3-iodopyrrolidines is carried out under mild conditions and in good yields, using a sequential radical decarboxylation–oxidation–iodination–arylation reaction. These iodinated pyrrolidines are valuable precursors of other compounds. For instance, they can be cyclized to tricyclic compounds or undergo dehalogenation to 2-aryl-2,5-dihydro-1H-pyrroles, which are iminosugar and 2-arylpyrrole precursors. This process provides a short pathway to a variety of alkaloid and drug analogues of potential pharmaceutical interest.
Publisher version (URL)https://doi.org/10.1039/C4OB01372G
Identifiersdoi: 10.1039/c4ob01372g
issn: 1477-0520
e-issn: 1477-0539
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.