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Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

AuthorsComas, Laura; Polo, Ester; Domingo, María Pilar; Hernandez, Yulán; Arias, Maykel; Esteban, Patricia; Martínez-Lostao, Luis; Pardo, Julián; Fuente, Jesús M. de la; Gálvez Buerba, Eva Mª
KeywordsMagnetic nanoparticles
Drug delivery
Cancer cells
Issue Date2-Apr-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationMaterials 12(7): 1092 (2019)
AbstractGliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.
Publisher version (URL)http://dx.doi.org/10.3390/ma12071092
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