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Title

Nucleoside analogues: Synthesis and biological properties of azanucleoside derivatives

AuthorsHernández, Dácil ; Boto, Alicia
KeywordsNucleosides
Nitrogen bases
Nucleotides
Azanucleosides
Nitrogen heterocycles
Medicinal chemistry
Issue DateApr-2014
PublisherWiley-VCH
ChemPubSoc Europe
CitationEuropean Journal of Organic Chemistry 2014(11): 2201-2220 (2014)
AbstractThe azanucleosides are nucleoside analogues where the furanose ring is replaced by a nitrogen‐containing ring or chain. Many azanucleosides are potent antiviral, anticancer and antimicrobial agents, or serve as valuable components of oligonucleotides with improved stability, binding or hybridization properties. Therefore, the development of new analogues is a very active area in medicinal and synthetic chemistry. Their synthesis and their interesting biological properties are discussed in this microreview.
Publisher version (URL)https://doi.org/10.1002/ejoc.201301731
URIhttp://hdl.handle.net/10261/179997
DOI10.1002/ejoc.201301731
Identifiersdoi: 10.1002/ejoc.201301731
issn: 1434-193X
e-issn: 1099-0690
Appears in Collections:(IPNA) Artículos
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