Nucleoside analogues: Synthesis and biological properties of azanucleoside derivatives

Abstract

The azanucleosides are nucleoside analogues where the furanose ring is replaced by a nitrogen‐containing ring or chain. Many azanucleosides are potent antiviral, anticancer and antimicrobial agents, or serve as valuable components of oligonucleotides with improved stability, binding or hybridization properties. Therefore, the development of new analogues is a very active area in medicinal and synthetic chemistry. Their synthesis and their interesting biological properties are discussed in this microreview.