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Title

Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation

AuthorsCarbajo López, Daniel; Fransen, Peter Paul K.H.; El-Faham, Ayman; Royo, Miriam; Albericio, Fernando
KeywordsSynthesis of Liraglutide
Peptides
Fragment condensation
Issue Date14-Mar-2019
PublisherAmerican Chemical Society
CitationOrganic Letters 21 (7): 2459-2463 (2019)
AbstractA handle for the protection of the C-terminus of peptides after cleaving with low concentration of trifluoroacetic acid (2-4%) is reported. The handle prevents polymerization reactions in the convergent condensation of peptidic fragments. Moreover, it is traceless, being removed during the final deprotection step of the peptide synthesis. This cheap and convenient handle is easily attached to the solid support, causing no disturbance to peptide elongation and thus proving to be useful in the convergent synthesis of long peptides. © 2019 American Chemical Society.
Publisher version (URL)https://pubs.acs.org/doi/abs/10.1021/acs.orglett.9b00813?af=R
URIhttp://hdl.handle.net/10261/179976
DOI10.1021/acs.orglett.9b00813
Appears in Collections:(IQAC) Artículos
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