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| Title: | Chloro-furanocembranolides from Leptogorgia sp. improve pancreatic beta-cell proliferation |
| Authors: | Gallardo, Amalia; Díaz-Marrero, Ana R.  ; Rosa, José M. de la ; D'Croz, Luis; Perdomo, Germán; Cózar-Castellano, Irene ; Darias, José ; Cueto, Mercedes |
| Issue Date: | 2-Feb-2018 |
| Publisher: | Molecular Diversity Preservation International |
| Citation: | Marine Drugs 16(2): 49 (2018) |
| Abstract: | Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells. |
| Description: | This article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds. |
| Publisher version (URL): | https://doi.org/10.3390/md16020049 |
| URI: | http://hdl.handle.net/10261/179477 |
| Identifiers: | doi: 10.3390/md16020049 issn: 1660-3397 |
| Appears in Collections: | (IBGM) Artículos (IPNA) Artículos |
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| chloroprolif.pdf | 1,83 MB | Adobe PDF |  View/Open |
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