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Chloro-furanocembranolides from Leptogorgia sp. improve pancreatic beta-cell proliferation

AuthorsGallardo, Amalia; Díaz-Marrero, Ana R. ; Rosa, José M. de la ; D'Croz, Luis; Perdomo, Germán; Cózar-Castellano, Irene ; Darias, José ; Cueto, Mercedes
Issue Date2-Feb-2018
PublisherMolecular Diversity Preservation International
CitationMarine Drugs 16(2): 49 (2018)
AbstractTwo new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.
DescriptionThis article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds.
Publisher version (URL)https://doi.org/10.3390/md16020049
Identifiersdoi: 10.3390/md16020049
issn: 1660-3397
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(IPNA) Artículos
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