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Bacterial Amyloids

AuthorsMarcoleta, Andrés; Wien, Frank; Arluison, Véronique; Lagos, Rosalba; Giraldo, R.
sRNA regulation
Plasmid replication control
Microcin E492
Issue DateMar-2019
PublisherJohn Wiley & Sons
CitationEncyclopedia of Life Sciences March (2019)
AbstractAmyloids are supramolecular protein assemblies based on fibrillar arrangements of β- sheets that were first found as linked to neurodegenerative and systemic human diseases. However, there is now overwhelming evidence on alternative roles of amyloids as functional assemblies and as epigenetic determinants of beneficial traits, both in Fungi and Metazoa. Bacteria also use amyloids as functional devices, mainly as extracellular scaffolds in biofilms, but there is increasing evidence for functional roles of amyloids in the bacterial cytosol, and these have enabled to engineer minimal models of a ‘generic’ amyloid disease. Amyloids are thus key players in the physiology of bacteria and versatile building blocks in Synthetic Biology.
Publisher version (URL)http://dx.doi.org/10.1002/9780470015902.a0028401
Appears in Collections:(CNB) Artículos
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