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Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media

AuthorsAtcher, Joan; Solà Oller, Jordi ; Alfonso, Ignacio
Dynamic combinatorial
Issue Date22-Nov-2016
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 15 (1): 213-219 (2017)
AbstractA straightforward four-step synthesis leads to the preparation of C2-symmetric dithiols containing a central aromatic core and amino acid side chains. These building blocks allow the preparation of dynamic covalent libraries of pseudopeptidic macrocycles in aqueous media that cover a broad range of polarities, functional groups and bulkiness mirroring the diversity found in natural peptides. The versatility of the generated dynamic libraries has been illustrated by the amplification of two different members from the same library upon the action of two biologically relevant templates. © The Royal Society of Chemistry
Publisher version (URL)10.1039/C6OB02441F
Appears in Collections:(IQAC) Artículos
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