English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/179165
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

3′-Hydroxy-3,4′-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK

AuthorsEstévez-Sarmiento, Francisco; Hernández, Elisa; Brouard, Ignacio ; León, Francisco ; García, Celina; Quintana, José; Estévez, Francisco
KeywordsCytotoxicity
Apoptosis
Cell cycle
Caspases
Flavonoids
Issue Date25-May-2018
PublisherElsevier
CitationChemico-Biological Interactions 288: 1-11 (2018)
AbstractFlavonoids are phenolic substances that appear to exert beneficial effects in several chronic diseases, including cancer. Structure-activity relationships of the cytotoxic activity of a series of flavonols and their 3-methyl ether derivatives established that 3′-hydroxy-3,4′-dimethoxyflavone (flavonoid 11) displayed strong cytotoxicity against human leukaemia cell lines (HL-60, U-937 and MOLT-3), and cells that over-express the anti-apoptotic proteins, Bcl-2 and Bcl-x, and against P-glycoprotein-overexpressing K-562/ADR cells. This compound induced G-M cell cycle arrest and it was a potent apoptotic inducer on HL-60, MOLT-3, U-937 and U-937/Bcl-2 cell lines. Cell death was (i) mediated by caspase activation, since it was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by a selective caspase-9 inhibitor, (ii) associated with cytochrome c release, the dissipation of the inner mitochondrial membrane potential (ΔΨ) and the activation of the mitogen-activated protein kinase pathway and (iii) partially blocked by the inhibition of c-jun NH terminal kinases/stress activated protein kinases (JNK/SAPK) signalling and by the free-radical scavenger N-acetyl-L-cysteine.
Publisher version (URL)https://doi.org/10.1016/j.cbi.2018.04.006
URIhttp://hdl.handle.net/10261/179165
DOIhttp://dx.doi.org/10.1016/j.cbi.2018.04.006
Identifiersdoi: 10.1016/j.cbi.2018.04.006
issn: 1872-7786
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.