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Título: | Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers |
Autor: | González-Correa, José Antonio; Rodríguez-Pérez, María Dolores; Márquez-Estrada, L.; López-Villodres, J.A.; Reyes, J.J.; Rodríguez-Gutiérrez, Guillermo CSIC ORCID ; Fernández-Bolaños Guzmán, Juan CSIC ORCID ; Cruz, José Pedro de la | Palabras clave: | Neuroprotection Hydroxytyrosol Cardiovascular biomarkers Diabetic retinopathy |
Fecha de publicación: | 2018 | Editor: | ACS Publications | Citación: | Journal of agricultural and food chemistry 66: 637- 644 (2018) | Resumen: | The aim of the study was to test the neuroprotective effect of hydroxytyrosol (HT) on experimental diabetic retinopathy. Animals were divided in four groups: (1) control nondiabetic rats, (2) streptozotocin-diabetic rats (DR), (3) DR treated with 1 mg/kg/day p.o. HT, and (4) DR treated with 5 mg/kg/day p.o. HT. Treatment with HT was started 7 days before inducing diabetes and was maintained for 2 months. In the DR group, total area occupied by extracellular matrix was increased, area occupied by retinal cells was decreased; both returned to near-control values in DR rats treated with HT. The number of retinal ganglion cells in DR was significantly lower (44%) than in the control group, and this decrease was smaller after HT treatment (34% and 9.1%). Linear regression analysis showed that prostacyclin, platelet aggregation, peroxynitrites, and the dose of 5 mg/kg/day HT significantly influenced retinal ganglion cell count. In conclusion, HT exerted a neuroprotective effect on diabetic retinopathy, and this effect correlated significantly with changes in some cardiovascular biomarkers. | URI: | http://hdl.handle.net/10261/179095 | DOI: | 10.1021/acs.jafc.7b05063 | Identificadores: | doi: 10.1021/acs.jafc.7b05063 issn: 1520-5118 |
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