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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/17872
Título

Identification of Urolithin A as a Metabolite Produced by Human Colon Microflora from Ellagic Acid and Related Compounds

AutorCerdá, Begoña; Periago, Paula María; Espín de Gea, Juan Carlos ; Tomás Barberán, Francisco
Palabras claveEllagitannin
Ellagic acid
Polyphenol
Metabolism
Colonic microflora
Dihydroxy-6H-dibenzo[b,d]pyran-6-one
Urolithin A
Walnut
Pomegranate
Punicalagin
Fecha de publicación17-jun-2005
EditorAmerican Chemical Society
CitaciónJournal of Agricultural and Food Chemistry 53(14): 5571-5576 (2005)
ResumenDietary ellagic acid and related polyphenols are metabolized in humans to dibenzopyran-6-one derivatives, and the microbial origin of these metabolites has been suggested. However, this has not been demonstrated so far. Fecal samples donated by six volunteers were incubated under anaerobic conditions, and aliquots were used to evaluate the fecal metabolism of ellagic acid, the ellagitannin punicalagin, and an ellagitannin rich extract from walnuts. The isoflavone daidzein was also incubated with the same fecal samples to follow the production of the microbial metabolites previously reported (dihydrogenistein, O-demethylangolensin, and equol) as a positive control of the system and to evaluate similarities between isoflavone and ellagic acid fecal flora metabolism. After fermentation the metabolite “urolithin A” (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one) was produced from ellagic acid, punicalagin, and the ellagitannin extract in all the fecal cultures from different volunteers, but with very different production rates and concentrations. This large variability in the concentration of metabolite and kinetics of metabolite production is consistent with the large variability found in the excretion of these metabolites in urine in vivo after human consumption of ellagitannins, and with differences in the composition of the fecal microflora. No correlation between isoflavone and ellagic acid metabolism by fecal microflora was observed. The present study confirms the microbial origin of the recently reported in vivo generated hydroxy-6H-dibenzo[b,d]pyran-6-one derivatives in humans and is a further step in the study of the bioavailability and metabolism of ellagic acid and ellagitannins.
Descripción6 pages, 3 tables, 4 figures.
Versión del editorhttp://dx.doi.org/10.1021/jf050384i
URIhttp://hdl.handle.net/10261/17872
DOI10.1021/jf050384i
ISSN1520-5118 (Online)
0021-8561 (Print)
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