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Intraorganellar acidification by V-ATPases: A target in cell proliferation and cancer therapy

AuthorsHernández, Agustín ; Serrano, Gloria; Herrera-Palau, Rosana ; Pérez-Castiñeira, J. R. ; Serrano, Aurelio
Issue Date2010
PublisherBentham Science Publishers
CitationRecent Patents on Anti-Cancer Drug Discovery 5: 88- 98 (2010)
AbstractV-ATPases are multicomponent proton pumps involved in the acidification of single membrane intracellular compartments such as endosomes and lysosomes. They couple the hydrolysis of ATP to the translocation of one to two protons across the membrane. Acidification of the lumen of single membrane organelles is a necessary factor for the correct traffic of membranes and cargo to and from the different internal compartments of a cell. Also, V-ATPases are involved in regulation of pH at the cytosol and, possibly, extracellular milieu. The inhibition of V-ATPases has been shown to induce apoptosis and cell cycle arrest in tumour cells and, therefore, chemicals that behave as inhibitors of this kind of proton pumps have been proposed as putative treatment agents against cancer. The present review will summarize the major types of V-ATPase inhibitors and their mechanisms of action and put them in relation to the patents registered so far for the treatment of cancer.
Identifiersissn: 1574-8928
Appears in Collections:(IBVF) Artículos
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