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Título: | Microbiological transformation of two 15α-hydroxy-ent-kaur-9(11),16- diene derivatives by the fungus Fusarium fujikuroi |
Autor: | Fraga, Braulio M. CSIC; González-Vallejo, Victoria CSIC; Guillermo, Ricardo CSIC; Amaro, Juan M. | Palabras clave: | 15α-Hydroxy-grandiflorenic acid Gibberella Fujikuroi 15α,18-Dihydroxy-ent-kaur-9(11),16-diene Fusarium Fujikuroi Diterpenes Biotransformations |
Fecha de publicación: | 8-feb-2013 | Editor: | Elsevier | Citación: | Phytochemistry 89: 39-46 (2013) | Resumen: | The incubation of 15α-hydroxy-ent-kaur-9(11),16-dien-19-oic acid (15α-hydroxy-grandiflorenic acid) with the fungus Fusarium fujikuroi gave as main metabolite its 3β,6β-dihydroxy derivative, which by an oxidative decarboxylation afforded a 19-nor compound with a 4,18-double bond. Other substances obtained were a 3α-hydroxy-19,6α-lactone, 3β-hydroxy-6β,7β-epoxy-ent-kaur-9(11),16-dien-19-oic acid and 3β-hydroxy-6-oxo-ent-kaur-9(11),16-dien-19-oic acid. Moreover, the biotransformation of 15α,18-dihydroxy-ent-kaur-9(11),16-diene led to the isolation of the corresponding 3β-, 6β-, 7α- and 12β-hydroxy derivatives. Two metabolites formed by 16β,17-epoxidation of the last compound and of the substrate were also obtained. These results indicated that the presence of the 9,11-double bond in the substrate impedes its 7β-hydroxylation, which is necessary for the formation of gibberellins and seco-ring B ent-kaurenoids. However, this 9,11-unsaturation does not hinder a 6,7-dehydrogenation and further 6β,7β-epoxidation, characteristic steps of the kaurenolide biosynthetic pathway. | Versión del editor: | https://doi.org/10.1016/j.phytochem.2013.01.006 | URI: | http://hdl.handle.net/10261/178613 | DOI: | 10.1016/j.phytochem.2013.01.006 | Identificadores: | doi: 10.1016/j.phytochem.2013.01.006 issn: 0031-9422 e-issn: 1873-3700 |
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